I think a lot of people would bag on 'Edwina' but I think a lot of that is because he's a misogynist who was turned into a woman. I don't actually remember his quest very well, but I don't think it was a curse but a consequence of misreading a magic scroll. The girdle is cursed though, and I think it's flavor text sets its origin as a prank on some macho blowhard. Being cursed to become a woman is certainly a classical happening though, I'd be interested in Baldur's Gate's take on Tiresias, it's the sort of thing you'd expect from a certain type of fantasy.