I fully expect it to be some sort of tie in between FR and the world of DOS2. Would be consistent with the DOS2 content already slated for Launch.
I severely doubt it's this. Firstly, because the DOS2 content are optional Easter eggs you only get with a deluxe edition, not stuff that's meaningfully embedded in the game world. Secondly, I can't imagine Larian wanting to tie their own setting to WotC like that. Any tie between the worlds big enough for Swen to be this excited and also to be bringing up the way he did would have to be fairly major, which could lead to awkwardness in the future when they continue with Divinity stuff.