Eh, Lolth might have been hot doo-doo back in 2nd or 3rd but 5th edition has seen her shrink rather...aggressively in stature as a deity. The retcons where the Udadrow/Aevendrow/Lorendrow stuff was introduced basically retroactively erased most of their presence in the underdark of Toril as a whole. A cult that Lolth hoodwinked into isolating themselves in a singular city in the underdark while drow with better sense (which is and apparently always was a majority) avoided. Meanwhile Lolth's motivations-,multiversal conquest, revenge against the Seldarine, shaping the drow through the brutal crucible of drow religion and society to be a reflection of herself, ambitions of drowing surface elves and humans into worship of herself....has eroded via the books into from what I can gather could best be described as 'lol, chaos' and ennui.
Plus y'know. aforementioned singular city where her worship is centered is
in the middle of a revolution.
As happy as I am to see she has something of a role in BG III (at least when you play a 'Lolthsworn' drow/cleric of Lolth), I am doubtful of 5e's version of Lolth to hold down the position of overarching villainess of the setting in her current state unless things drastically change.