My biggest fear... nobody will make me a homebrew Thri-Kreen race mod. Their leap ability with Larian's maps would be fun and they have 4 arms. I'm not holding my breath on this one though.
Next biggest would have to be Larian releasing a limited modding toolkit. I cant mod myself but have been using mods in games for decades. There is already a good amount of modding work being done for BG3 without official tools yet. I really want Larian to give the modding community as much access as they can. Nearly everything I'm not really a fan of gameplay/mechanics wise I hope to just mod the way I want. Hopefully someone can figure out a way to add true vertically, real flight/wall climb and 3D space representation/manipulation.