I' m starting to fear that the big surprise is that there will be not much left of Baldur's Gate once we arrive there:😅
The Cult tries to get their hands on runepowder, the Ironhand Gnomes already have some of it (and plan to use it), and everybody is heading towards Baldur's Gate.
Including Shadowheart and the mysterious artefact, of which I hope it is not the D20 of doom.
(And I hope nobody notices Gale's condition and tries to use him as a living bomb)

Just kidding, I think that, most likely, we can prevent that parts of the swordcoast are going to be destroid (if the information we get about the destructiveness of runepowder is correct, and it is really that devastating).