I would like consequences to our actions. If we save traders they give us better deals in act 2. If we kill NPC X in act 1 they they can't help us in act 2. I hope we can join / work with different factions in BG, and ok that we can't please everyone at a time (ie conflicting goals) so we help the assassin's in one playthrough and the magisters in the next.
And for combat...different rules of engagement. So an escort mission, rescue, platform, environmental, defend the castle, heist etc