Just to throw in another thought, the dead fisherman on the beach mentions survivors from the crash. A beautiful woman that people couldn't look away from, and an elf.

Who were they? Is it possible they were Z'rell and Ketheric? I guess I'm wondering what was really going on in the attack. Why did the githyanki follow the ship into avernus? Was it for the artifact? Was it because there were chosen of the absolute on the Nautiloid at the same time as the player characters?

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One of the things that don't work for me about karlach's story: why is she so important? Why is she so good at fighting on the front lines? It sounds far fetched and ridiculous. She's level one. I get that she says she was fighting with fire in her blood or some such, as provided by Zariel, but if that's the case, it sounds like the fire in the blood is the valuable resource, not Karlach. Just replace Karlach with some other level one unfortunate and jack the up with the devil juice.