By the way, and apologies if someone has already mentioned this, but the top hat with skull is giving me Baron Samedi vibes. I know FR lore often borrows from real world religions and mythologies. Is there anything in it based on Haitian Vodou?
Now that you mention it, I do believe that elements of voodoo play a role here. Drusilla seems to be related, perhaps in a role of voodoo priestess. She regards her dead sister (how did she die?) as still living somehow, and she deals in fetishes. Those fetishes seem to be particularly important. Firsty, there is the lucky rabbit's foot that was stolen from our pocket, presumably by mr. top hat. Secondly, there is an unspecified talisman hanging by our door. It was also a gift from Drusilla.
I am now thinking about rule number one in murder mysteries: the killer is always the least likely to have committed the murder(s). So maybe Drusilla is the killer (she was very close to the first crime scene and mentioned a shadowy figure running away, which is a classic way of diverting attention away from oneself)? And manybe the top hat fellow is actually an agent from Pinkerton (well, its forgotten realms equivalent) trying to protect us from Drusilla's evil influence?