Not just containers either. At the tollhouse, even when I pass the heck to know there should be a key somewhere around, I cannot for the life of me find the thing. Its so small and it doesn't highlight so its down to my physical eyes trying and failing to get it.
I am pretty sure there is a way to make the key "visible". I usualy use "Speak with Dead" on the dude who dropped the key.
One a side note, I do like that you as a player can't highlight a button until your character notices it - I am not a fan that you can find it anyway. Your character knows/notices it, or it doesn't. Player's ability to pixel hunt should be taken into account. (and yes, I think the same about BG1's secret stashes)