I'll probably play the origin characters myself.
But I have noticed a couple things in the game that feel like themes to me.
1. One Eye: there's Wyll with his sending stone eye, there's the Hag with her offer, there's Volo's eye that he happens to be carrying, one of the kids wears on eye patch
2. Rebirth: there's the gnoll that's born from the body of the dying hyena, there's the whole idea of the tadpole and what it does--transforming us into something "beautiful"