Originally Posted by Edvin Black
Let me give you an example:

"" I request to be able to play as a dwarf who suffers from a rare (one in a hundred million) form of gigantism and is two meters tall. ""
"" Given my height and bulk, I want a MASSIVE bonus to my strength and constitution. I'm willing to accept a certain penalty to dexterity and charisma. ""

It's technically a real thing. Such a dwarf could exist.
But should we be allowed to play as such a dwarf?
Definitely not!

If we are talking PnP DnD here, then I don't fully agree. If this idea gets a greenlight from both DM and every other player, then why not? But I doubt that other players will be fine with playing standard DnD characters while one particular person goes for an unhinged homebrew like this. They'll most likely either humble this person to play something standard or request the DM to lift limitations for them as well and become the party of gifted, altered and diseased. Which can off-set the whole balance of the campaign and will not likely be permitted.