As I continue to think about it I am starting to believe this particular origin will have much heavier ties into the original games than the regular custom character or other origin characters. Seems fairly obvious that you will be tied to Bhaal in some way and perhaps it emphasizes that part of the story far more.
I'm just not positive how much fun it will be to play if it is constantly reminding you (like if it modifies literally every dialogue and interaction) that you want to murder stuff.
As some other people have said it seems like a great option for a second play through. I imagine it changes quite a few things as you go through the game.
