Yes, fighter 5 for the dual wield, action surge and extra attack. The extra action from thief 3 gives an extra attack per round at the moment in EA so it is hard to see how assassin (as awesome as it sounds) could beat this. But as rodeolifant said, this is only if I don't play the rogue role with my main and rogues are so much fun in EA and the gloomstalker / thief or shadow monk / thief are pretty tempting.
And as tempting as it always is to kill Astarion, the first playthrough for me is always the completionist do everyone's side story playthrough.