Biggest thing is to know you can, and should think out of the box in combat.

Lots of game studioes thing of how players can beat fights first before thinking of immersion.

Larian focuses on immersion first. If you decided to face tank a roadblock checkpoint, you'll probably have a bad time.

If you decide to charge head long into a bad guy base, you'll probably have some problems.

Also know that npcs will lie to you.