I think "miss out" is approaching the game in the wrong direction. A Tavric of Bhaal will experience the content one way. When you repay as SH origin you'll experience the content entirely diffently.
The thought of only playing this game once seems anathema to me, and these worries of "missing out" feel like they come from a single playthrough assumption. In any one playthrough I'm not missing out on any content, I'm getting the story of that character. And my next character, whether Durge, origin, or Tav will have a completely different story