Well, I guess it's ambitious to lock a lot of content behind a mechanic that only makes sense as a hammy 70's body horror fetish and/or fantasy version of 50 shades of gray. It's not like moving Daisy from your hearts desire to the status of a Guardian, does anything to alter or hide the only narrative reason given in chapter 1 to go down the brainworm farmer path is to get terminally screwed, body, mind and soul. Even if this plotline is partly intended to work as joking social commentary or whatever, it's not a good design choice from Larian to dedicate whole branching plotline behind enganging with fetish content.
I'd say the better games in the genre(Resident evil village, System shock etc.) that fetishize body horror, tend to leave it mostly up to the player whether or not they want to engage with this stuff or not, and leave enough room for the players to treat the story as just a horror story. In BG3 it's like we're sort of stuck with a GM that's trying to coerce the players to engage with his/her fetish.