Their own IP does not need to appeal to the source material thats why they can express creativity more. There will be not much controversy and pressure from the outside like we have now with the new changes. I honestly want them to make a product of their own passion while not being tied by some external factors and conservative opinions. Stability kills creativity, as we've seen with a lot of Ubisoft titles for example. With DOS2 Larian proved that are willing to experiment by shaking the core mechanics of crowd control with the new armor system (which I find not at all perfect), as well as the origin. characters system and verticality.
It would arguably makes things easier but it would not lead to a better game. Less arguments about rule sets or rule changes and so on but D&D is still the best...at least for the time being. Although I think that if left to their own devices WotC will run D&D into the ground so in 5 or 10 years there may well be no D&D worth speaking of. Though it is worth noting that what I said previously was wrong...the rules of D&D 5e are published under an open game license...meaning anyone can use them as they wish, they just can't call it D&D. The first edition of Pathfinder is basically a slightly modified D&D 3.5. This may be the lease on life Larian need here. Use the rules of 5e as allowed by OGL, maybe with minor tweaks and run away as fast and as far as possible from WotC before they ruin D&D forever.