I think min-maxing is kinda bad for the first run (at least), especially if you care about the story/rp as well. Some decisions that are considered to be min-maxing can create a major disconnect between what you want to do story-wise and what you 'have' to do in order to gain the most gameplay benefit. For example you want to use the Absolute's items while playing as Wyll, who is disgusted by goblins. Letting one brand you kinda kills the whole vibe. There are many examples like this.
