Swen has mentioned he doesn't want to do anything this big again iirc, and that Larian has sort of ballooned in size (up to ~500ish people) that he wants to sort of cut down into smaller teams. I expect smaller projects going forward, but suppose we'll see.
I think that would be a very smart thing to do. Since they did D:OS1 they have been working and expanding the same formula. It feels like BG3 might be the game, in which they do all they wanted to do with it. It would make sense to explore new ideas next.