I am most interested in Shadowheart and Minthara personally. Particularly interested in seeing where their personal quests go. Though I might end up romancing Lae'zel later down the line in my latter playthroughs as well. My first playthrough I'll be a Rogue Assassin Dark Urge so I'm thinking I'll romance Minthara first. I don't particularly care much for Karlach...seems a bit too stubborn about being good, and that's not what I'll be doing...maybe if there is an interesting way to corrupt her then maybe.