Even Astarion? He's a bloody vampire spawn ... which means he's evil and rotten to the core with no redeeming features whatsoever. Allowing such an abomination to exist is unthinkable.
Who speaks there? A particularly fundamentalist paladin? I judge everyone as an individual, and so far he's done nothing that justifies killing. Being a vampire doesn't mean anything but that you require blood to survive and you have certain unusual traits, such as not dying from old age. Have you played BG2? Those liches you destroy on your misplaced quest to get Kangaxx his bones? They were actually good, they had sacrificed themselves to guard those bones beyond their mortal lives in order to prevent the evil uber-lich Kangaxx from returning.
Actually a fundamentalist Kelemvorite... undead are an abomination in Kelemvor's eyes and must be destroyed.
And no, I've never played BG2 that far... I hate the tutorial (Jon Irenicus' dungeon) so much, it actually turned me off from playing and I most likely won't do it ever again.
But I never understood the desire for playing vampires outside of WoD (and even there I'd rather play a werewolf or a hunter). As for Astarion ...
he hasn't attacked you in our sleep trying to feed?
Being a vampire means a lot more than just being immortal in D&D...