I make my first Tav as per the 'what's your backstory' thread, and will make choices according to what Tav would do. I would do that without respeccing, and even reloading unless there's a bug or something. A TPK or other way of game over, is the end of Tav's story.
I will then play as Shadowheart and do the same.
Then a Dark Urge and do the same.
I haven't planned further than that, but I will more or less do that until I beat the game.
Note: I would definitely respec Shadowheart if she's converted to another faith - which is something I can really see happening. It makes way more sense if another Deity, another outlook would and should offer Different spells and abilities.
