Yes, one character playthrough all the way to the end of the story before starting another. First run: Dark Urge Wood Elf Rogue Assassin though I might be inclined to switch to Drow if the subraces get some kind of bonus in the final game as in early access Drow subraces do nothing but add some conversation options. Planned party members: Shadowheart, Minthara, and Lae'zel.
No plans to ever respec or multiclass anyone in my party.
Definitely not starting a bunch of playthroughs at once.