I will not respec since it will ruin the game imo.
The first playthrough will probably be the most fun since everything is new so I will choose carefully when creating my character. Whatever I'll play in a second playthrough will probably depend on what I encountered in my first playthrough, since I will then be better equipped to make a character who will fit into the universe in an interesting way. For instance not much fun in playing a druid if most of the action takes place in the city.
