Something I've been contemplating is that people keep bringing up loss of companions and their associated content as a trade off for the tadpole path. But we know that there are other ways to make companions abandon us, presumably even if we don't interact with the tadpoles. And we know at least Astarion will likely stay since so far he's the only one advocating for keeping keeping tadpole. So how balanced is it to be "gaining" content that we can still lose in another way anyway? Plus we will presumably still be gaining different story content based on embracing the tadpoles, not including the powers themselves. So saying we lose out on content may not be entirely accurate, unless you say we also lose out on content going the good, anti tadpole route.

The more I think about it, the more I think that embracing the tadpole to a significant extent is the intended way to play, since Larian has said we can use the power for good. But I think rejecting it completely isn't how the story is meant to play out.