So far my 8 Charisma druid has succeeded on something like 80% of his Charisma checks through a combination of Guidance, Enhance Skill, and careful use of Inspiration Points. The times he did fail didn't end in brutal combat or life-and-death situations because I've been selective about where and to what end I use the charisma options to try and get a better outcome. I'm about 30 hours in right now.
Guidance is honestly so good. It automatically compensates for your deficit -1 no matter what and can be the equivalent of a +3 in CHA if you get a max roll.
