Alright Silver I’ve made the mistake of reading your spoilers before, so just tell it to me straight as yes or no:
I want to play and end the game with a fully autonomous, free, and healthy mind and body. Will not using the tadpole powers or eating any tadpoles help me in this effort?
Nope. No. Not at all. Nada. Negative.
... :\
However, some endings are much harder to achieve than others. One has a DC 99 check after two more difficult checks. If you don't know what you're doing, some endings CONSIDERABLY increase the risk of dying. It's not all sunshine. Savescummers are just not going to be harmed by that. The rolls you have to pass aren't necessarily charisma at least, but of your choice.