I turned on karmic dice yesterday and played a bunch (too much :D) and it seemed better, not nearly as many nasty streaks. I didn't notice it working against me either, although in Act 3 now, everything is fairly high level, so many the karmic dice are working in my favor. I'm only level 9, and a lot of boss type encounters seem to be 10/11 with minions between 8 - 9.
