Instead, Gale can fix his condition with a few cheap baubles and reclaim his place as Mystra's lover. Lae'zel comes out the other side of her crisis of faith as a full-on revolutionary. Wyll can escape his pact and save his father. Tav's illithid powers have no consequence. But Karlach can't fix her engine, can't even look into it. Karlach has to die to serve a thematic point that no longer exists. So, it doesn't feel poignant or meaningful, but just kind of mean and bizarre.
Yeah, its all this that make it sting the most. It makes Karlach feel like an afterthought in the world despite how impactful she's been to everyone that's encountered her ingame. A fetch quest into a kill quest, when the solution to her problem sits right there in act 3. Painful.