i have a similiar situation but since it would be spoiler for act 3 for the OP i'll put it into spoiler:
The game doesnt crash if i save inside the iron throne but once i leave it saving or changing region crash the game, i have a save file just outside of the submarine before entering the iron throne and i can change region and save without any problem.
- I tried not saving anyone or picking up anything in the prison, even just triggering omuulum dialog and going back to the submarine
- dropping or sending to camp all my inventory (keys,food and gold included)
- checking for dead npc with still HP left
(i couldnt check some corpses because in bhaal temple they just disappear into thin air)
- tried moving the save file on 3 different pc with different option configurations and with either windows 10 or 11
- checking stash and inventory for any corrupted item like an another user suggested with some bottle of wine having the name <NOT FOUND>
- playing offline and without cloud sync
- deleting levelcache
- checking game files
nothing seems to work and i'm already 100 hours into the game and near the end of the game, so i have to choose between ignoring that specific quest, do it and rush to the end of the game without saving or wait for a fix.
I can try posting the save file if it is of any help
Version 4.1.1.3911062