I'm wondering, is there any reaction from the Nightsong if you
kill Isobel as the Dark Urge?
I would assume that there would be a reaction to the event but it's entirely possible that nobody outside of your companions ever finds out what transpired there...you can even deceive Jaheira. If you do that, you will encounter Isobel again when fighting Kethric given the particular set of powers he has and the connection he has with Isobel...but she will not be the same at all. Her attitude will be that of a very happy loyal servant of Kethric. I'm assuming that Nightsong and Isobel might be enemies in that event...and that might be fun to see.