Total fanfiction moment, but I would have been thrilled to be able to talk to Withers and somehow trade my player character's life for Karlach, or something similar. I'm all for a self-sacrificial moment if it saves a loved one. Cheap heart string pulling moment, but I'm all for sappy shit like that.
Considering Withers is the "servant" of Acererak the lich, trading Karlach soul with PC soul could lead to an epic crossover between Acererak unleashing his power and Zariel fighting this false god in the name of her Fury of the Avernus. Here comes the Doom