I am half-considering making a "mundane BG3" mod and strip out most items just to see how it plays with less gear and consumables. I find the game to be reasonably easy, so I think it might a good way to make the middle difficulty option feel right, give power back to casters, and reduce overall clutter. Also some gear is just stupid OP that should exist in it's current form.
I'm all for less magic items, but it must be done carefully. I think healing potions and poison antidotes should still be plentiful and widely available.
What I'd really love to see is mod that removes the special arrows from the game, especially the multi-target and lightning ones. Other magic items should be changed in accordance with the DMG.
I'm not sure whether it is a good idea without adjust the stats, abilities and HP of enemies first though.