You know, I look at some of the posts in this thread and I'm like: did you guys even PLAY the game?!?! Were you even paying any ATTENTION?!?! It all seemed pretty obvious to me. Ketheric and his wife were Selunites, and were raising Isobel-their daughter-as a Selunite as well. When his wife died, Ketheric turned to Shar in despair (all of which you learn from last year's trailer).....and I suspect either he or another Sharran was involved in Isobel's death, due to her being a Selunite Cleric (remember that killing a Selunite is the final step in becoming a Dark Justiciar). her death certainly wasn't natural-even by Faerun standards-as she mentions to you how there was nothing but darkness upon her death, instead of her going to the Upper Planes upon her death. Ketheric resurrected Isobel after he turned to Myrkhul, and almost certainly after he'd Soul Chained Dame Aylin in return for immortality & invulnerability. I don't doubt that Shar had been wanting Aylin's death for 100 years, and Shadowheart was the first Sharran in all that time that was in the right place to actually do the deed.

No, none of it is connected to BG1 or BG2, which are entirely dedicated to the Bhaalspawn and their machinations, but the story is VERY Forgotten Realms and VERY D&D.