I crash probably 2-3 times an hour, sometimes more, sometimes less. I've tried on both Vulkan and DX11, same story. I've had to redo story sequences numerous times and crashed in the middle of difficult fights, having to redo them again, it kinda forces me to save scum just in case i crash. DX11 was straight up unplayable in Act III after 45-60min.
Windows 11
I9-13900K
64GB of RAM
4080
All drivers up to date. It's been doing it from day one, normally I wouldn't deal with it and would just refund but, well, 130 hours and it's a little hard, but the game is so good. I deal with it but it's infuriating and like I have to roll to keep the game running (this is my sad attempt at a joke). You shouldn't have to jump through a bunch of hoops to avoid the game crashing, it should work, there are clearly some problems here and I don't think BIOS/gpu settings are at fault.
The game is just buggy, it gets worse as the game goes on and I crash a lot more in Act III than I do in earlier acts.