First I would make sure that this is only a BG3 issue by putting in a couple of full sessions on at least two other games.
If it turns out to be happening with others games then I would physically check inside the case to make sure that fans (including the PSU fan) are working and that heat-sinks aren't clogged up.
If it does turn out to be just BG3 then I would make a careful note of where and when the crashes happen and how long I had been playing for. If you can reproduce a crash either by time and place or by length of game play then send a report to Larian.