First: Nobody is saying that the problems are all mod-related. Basic trouble-shooting principles say that the first thing you do is eliminate non-essential elements - that's why we look at mods first.
Second: If your game has problems after a hotfix or patch remove the patch.
Third: Or you could try running the game directly from the exe. bg3.exe for Vulkan and bg3_dx11.exe for DX11.

Pro tip #1: Turn off any automatic updating of anything on your computer. That way when you manually download stuff you have a better idea of what is happening on your machine. It also means that others are being the guinea pigs for hotfixes and patches.

Pro tip #2: Learn how to do things. Stop relying on Steam and GOG and Nexus and wabbajack and the rest to hold your hand and do everything for you. They don't do it for you, they do it for them.