Hotfix #5 hasn't solved my issue either - my main save in act 2 loads all the way up to 60%, then crashes to desktop. Windows event viewer says the crash is related to ntdll.dll? I've tried running vulkan, dx11, rolling back the hotfixes, reinstalling, etc... nothing seems to work to fix it. I have mods but I'm able to create a new save/game just fine and I haven't changed any mods aside from updating the ones that required an update after the patches.. but I've even rolled back the mods to test along with rolling back the update to no avail. No clue what's going on. Just want my act 2 save back!

Doing a slightly sassier run on my new save in the mean time...