Same for thing me... Hotfix #5 has totally broken the game for me.
Every load screen, every dialogue load, the game freezes where I am able to move the camera and even 'glide' my character around... but I am unable to do anything. The game crashed once and I had to Verify the files before I could play again.
But this did not fix the problem.
I have NO mods installed.
I reinstalled the latest graphics drivers.
Verified Integrity of game files.
Lowered my graphics settings.
I have never had this problem in the 1-2 years I have played this game, early access had fewer issues.
I love BG3, I hope that they are able to fix this 'hotfix'.