I've gotten some new (to me) dialogue with Karlach in Acts I and II - very short scenes which emphasize the increasingly desperate nature of her condition.
But... her condition isnt even that bad...
It's very much that bad, which the new scenes are mostly there to emphasize, I think. It's not physically debilitating at the moment - for gameplay reasons, I'm sure - and you can even throw soul coins on the fire with perfect safety. But she's in pain and her time is short.