Well, I played the entire first playthrough because they talked so much about choice and consequence. Turns out I resisted for nothing, but, if they add in some actual consequence etc loosing your sense of self, you have to do checks to resist eating brains and so on. Then this can at least be mediated somehow.

Regarding your Wish example, there is a really easy fix for this. Just.. dont include Wish? It is not like they have implemented EVERY feat, class and spell from DnD lvl 1-12 anyway.