I haven't finished the game yet, my merry bands of adventurers are currently playing out act 2, but on two occasions I have had trouble with establishing cardinal directions.
The first:
In the quest for Lathander's blood, we were supposed to turn statues. One for the rising sun, the other for the setting sun. But turning the statues to face east and west didn't solve the puzzle. Turning them north and south did.
The second:
The silent library in Shar's temple. Instructions told us we should press the button in the northwest. But the northeastern button was the one that opened the gate.
Some background: I have the mini map set to always face north, I am not sure how the sun actually rises and sets on the D&D planet (sorry, I don't know the name). But the fact is that on two occasions I had to rely on the compass, and on both occasions the compass failed me. Is there something wrong with me, or is it something that needs to be fixed?