And it sounds like Durge might have been tadpoled by her - but it would be helpful if someone with a Durge playthrough (mine isn't far enough) could check if she says something about that. Because she is interested in studying thralls and she is speaking about Durge having still parts of its own mind despite having a parasite (see above).
Apparently, durge was the first tadpoling victim. I don't remember what exactly she says, but I didn't get the impression that she did it - just that she found them on the floor, near death, patched them up and kept cutting them open and healing them again and again, developing a very unhealthy relationship while doing it. The durge definitely wasn't very functional during this time, as she's never even heard their voice before.
Regarding no reaction by Balthazar - it seems like Ketheric gives no reaction to Durges too from what I have heard from others. Maybe bug/no time left/forgot about it...?
Ketheric recognizes the durge, but he doesn't have that much to say about it. Just tells them he hopes they're there to help rather than cause trouble and to respect his authority. By his subdued reaction, I'm assuming he doesn't even know what happened to them - just that one day they disappeared and Orin took their place. (It's kinda weird in retrospect, ofc the real reason he doesn't have more to say is so that too much of the story isn't given out too early)