Maybe it does for some, but that is not the cause for all. I opened a previous save that included no mods and it doesn't work. I uninstalled all mods, removed their pak files from the mod directory, opened a previous save with no mod associated with it and it didn't work. I started a new game, it worked. I added mods to the new game, saved, reopened the save and it still worked.

This issue along with the Failed to Save 516 error after trading with a vendor only seems to show up if I open a previous patch 3 save.