There has been absolutely no indication from Larian that they're willing to make changes to Karlach's railroaded storyline. They seem to be very happy what they currently have. And it's within their right.
I would love to have a happy ending for her in addition to the ones currently in the game. But just don't get your hopes up.
They are probably happy only with the fact, that you can complete Karlach storyline from beginning to the end without blocking bugs. With removed content the whole infernal engine story remains one big empty nonsence with bring 2x infernal ore and then let her die, nobody cares. If Swen or somebody from the core team played the game from the start to the end with Karlach in party and observed the empty journal at the end (compared to other origin characters), don't tell me, he said. "Wow, we did awesome job, the quest is just great and the ending is exactly as I expected"
So I don't give up, DE has to come I do hope, (un)fortunately not earlier, that a year from now.