The more I think about it, there is NO SHOT the writers are satisfied with her story at the moment.

For instance; you could, hypothetically, enter Act 3, head directly to Gortash, kill him within the first 15 minutes of the final act, get Karlachs monologue and the quest log will say "We tried everything we could" BEFORE YOU EVEN ENTER THE CITY.

Larian would have to be full, top to bottom, of the most incompetent game developers possible for them to think that is ok.