Here's what I've seen:

- Strange Ox transforms the moment I enter Last Light Inn in Act 2 for the first time. Kills all NPC's in sight, and then despawns - this is usually just Dammon, but that breaks Karlach's quest.

-Trade glitch.

-Full game crash, graphical error code, will update what it is next time.

-Harper Scouts dialogue before Harpers/Shadows fight scene triggers very early, making it impossible to save the Harper Scouts. (I was about 50m away from the NPC's in question).

-Key to WIndmill Cellar door in Act 1 seems to have vanished on a separate playthrough.