If playing with other players, simply communicate (voice comms?) and work out who does what when (it is frequently in your best interest to go at the same time, such as the second person moving to within melee range so the rogue who technically has the higher initiative can get a sneak attack).
That's all well and good except for the fact that this annoying (and unnecessary) split screen makes it very difficult to even tell where you are in relation to the person you are playing with. That and you can't tell if you are targeting the same enemy.