All my playthroughs now end after we deal with Cazador and Orin.
That's where a good number of my playthroughs end too. Avoids so many problems!
Sometimes I take SH to finish her quest. Have a chat with Gortash if I'm Durge. The rest just feels like a chore, especially the last fights when you know what kind of ending awaits you.
Yeah, in my case, my first playthrough was a completionist round. I even found all the clown parts.
But my second playthrough, I blitzed everything. Explored a few quests I didn't get last time.