Basically no. That is because, unlike the old games, there are no alignment/reputation pitfalls and everyone gets along with everyone else at least well enough to be in the same party. Because of these issues, the old games were much more limited than the number of possible companions would suggest.
What I do dislike much more is being limited to four characters in your active party. There are four roles in a versatile party, and being limited to four slots means you have no slot to take someone along just for fun or roleplaying. There are mods for that, but I think they mess with the balance and the interface is designed for four characters, so that's not really satisfactory. I've heard to you take Jaheira along in a summons slot for the fight for Moonrise Towers (in order to prevent her untimely death by stupid game AI), and I'd like to have that opportunity more often, and for all companions and camp followers. I wouldn't need to manage them as regular party members while they're in the summons slot, just take them along as they are and let them interact within the party and as party member with NPCs.
